Clinical signs of bromethalin intoxication
Clinical signs of intoxication can be classified as acute or chronic related to the amount ingested. The median lethal dose (LD50) for a variety of species is presented in Table 1. Ingestion of greater than two times the LD50 results in acute toxicosis. Signs include hyperexcitability, seizures, whole body tremors, pelvic limb ataxia and weakness, anisocoria, blindness, abnormal nystagmus, and coma. Death can result from respiratory arrest.3,5-7 Typically signs develop within eight to 12 hours but may occur as soon as two to four hours after ingestion.3
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